Pressure Studies of Protein Dynamics.

Abstract

The relation between dynamic structure and function of proteins is investigated. Protein dynamics are studied by observing the phenomena induced by flash photolysis using near ultraviolet, optical, and infrared spectroscopies over wide ranges in temperature (60-300K), time (50ns-Iks), and, pressure (0.1-200MPa). Initially we study a simple biomolecular reaction - carbon monoxide binding to myoglobin. Previous work over wide ranges in temperature and time has been crucial to developing models of protein dynamics. We developed a hierarchical model of protein dynamics which promises to contribute to understanding both biomolecular reactions and the physics of amorphous solids and glasses. The combined pressure and temperature experiments will test various features of the hierarchical model including the glass-like properties of proteins. Keywords: Proteinquake, flash photolysis, spectroscopic markers, ligand binding.

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Document Details

Document Type
Technical Report
Publication Date
Feb 20, 1987
Accession Number
ADA179028

Entities

People

  • Hans Frauenfelder
  • Robert D. Young

Organizations

  • University of Illinois Urbana–Champaign

Tags

Communities of Interest

  • Biomedical
  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Biochemistry
  • Biological Sciences
  • Carbon Monoxide
  • Chemical Engineering
  • Chemical Reactions
  • Chemistry
  • Classification
  • Decomposition
  • Dielectric Gases
  • Dynamics
  • Ecology
  • Low Temperature
  • Measurement
  • Military Research
  • Molecular Dynamics
  • Photolysis
  • Physics

Readers

  • Mechanical Engineering/Mechanics of Materials.
  • Molecular and Cellular Biochemistry
  • Spectroscopy.