Studies of the Biological and Molecular Basis of the Inhibition of Activity of Phagocytic Cells by Anthrax Toxin

Abstract

Pretreatment with anthrax toxin inhibits priming of polymorphonuclear neutrophils by lipopolysaccharide or muramyl dipeptide, resulting in reduction in release of superoxide anion when the cells are stimulated with chemotactic peptide. The resulting attenuation of critical antibacterial activities of neutrophils may represent an important mechanism of virulence in Bacillus anthracis. Keywords: Phagocytes, Superoxide Anion, Lipopolysaccharide; Bacterial toxins.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1986
Accession Number
ADA179095

Entities

People

  • George G. Wright
  • Gerald L. Mandell

Organizations

  • University of Virginia

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Adaptive Immunity
  • Albumins
  • Bacterial Toxins
  • Biological Toxins
  • Biomedical Research
  • Blood
  • Cell Physiological Processes
  • Cell-Free System
  • Cells
  • Cellular Structures
  • Chemistry
  • Escherichia Coli
  • Granulocytes
  • Microbiology
  • Phagocytes
  • Polymorphonuclear Neutrophils
  • Proteins

Fields of Study

  • Biology

Readers

  • Immunology
  • Molecular and Cellular Biochemistry