Chemical Preparation Laboratory for IND Candidate Compounds.

Abstract

During the reporting period eleven compounds were prepared and submitted: 1-beta-D-Ribofuranosy1-1,2,4-triazole-3-carboxamidine hydrochloride; methyl-4-chloro- 5-(2,4-dichloropheny1)-1(H)pyrazole-3-carboxylate; 3-deazauridine; 1-beta-D-ribofuranosy1-1,2,4-triazole-3-carboxamide (Ribavirin); 4-imino-pyrazolo3,4-D-thiazine-6(7H)thione; 7-carbamoy1-1-beta-D-ribofuranosylimidazo1,2-Bpyrazol-6-y1-methylsulfone; Lycoricidine triacetate; 2-beta-d-ribofuranoysl-selenazo-4-carboxamide; 2',3',5' -tri-0-acetyl-2-beta-D-ribofuranosyl-selenazo-4-carboxamide; 4H-r, 1H-trans, 2H-cis, 10bH-trans, 1-(2'-tetrahydropyranyloxy) 2-hydroxy-8,9-methylenedioxy-1,2,4a,10b-tetrahydro-6(5H)phenanthridone; 4aH-r, 1H-trans, 2H-cis, 10bH-trans-1,2-Dihydroxy-8,9-methylenedioxy-1,2,4a,10b-tetrahydro-(5H)phenanthridone. Three compounds remain under investigation: 3-Deazaguanine; Combretastation. Keywords: Nucleosides, antivirals, selenazoles, triazoles, alkaloids, formycin, nucleosides, ribavirin.

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Document Details

Document Type
Technical Report
Publication Date
Jan 30, 1987
Accession Number
ADA179119

Entities

People

  • Ernst M. Schubert

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alcohols
  • Alkenes
  • Anhydrides
  • Biomedical Research
  • Chlorides
  • Cold Water
  • Crystal Structure
  • Filtration
  • Hydrochloric Acid
  • Hydrogen
  • Hydroxides
  • Infectious Diseases
  • Materials
  • Nitriles
  • Osmium Compounds
  • Pyrazoles
  • Sodium Compounds

Fields of Study

  • Chemistry

Readers

  • Parasitology and Pharmacology of Malaria.