A Multidisciplinary Study of Ciguatoxin and Related Low Molecular Weight Toxins from Marine Source
Abstract
The work in this report deals with the isolation and purification of ciguatoxin from ciguateric fish, the pharmacology and toxicology of ciguatoxin and other toxins extracted from various assays and progress made on a system for detection of ciguateric fish flesh. Ciguatoxin has been isolated from livers and viscera of eels obtained from Pacific Islands where ciguatera is endemic. Evaluation of the pharmacology and toxicology has been both in vitro and in vivo systems but has been hampered by a shortage of purified toxins. The immunological stick method of assaying of ciguatera in fish has yielded interesting and promising results. Work on all of these aspects of ciguatera toxicity and toxicity to other marine toxins is proceeding at an accelerated pace.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1986
- Accession Number
- ADA179405
Entities
People
- James T. Miyahara
- Leslie E. Bailey
- Paul J. Scheuer
- Yoshitsugi Hokama
Organizations
- University of Hawaiʻi at Mānoa