Pharmacological Sparing of Protein and Glucose in Burn Injury and/or Sepsis.

Abstract

We have assessed the role of glucagon and sympathetic nervous system (SNS) activity on glucose and palmitate kinetics and oxidation in the conscious dog infused with live E. coli bacteria. These studies lead us to conclude that the lowering of glucagon concentration should have an important effect in reducing gluconeogenesis, and thus protein wasting. Manipulation of the sympathetic nervous system to enhance the mobilization of lipid, on the other hand, does not seem likely to be fruitful since there are already ample amounts of fatty acids available as energy substrates. Future studies will therefore focus entirely on minimizing protein breakdown directly and via suppression of gluconeogensis, and adrenergic blockade will not be pursued.

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Document Details

Document Type
Technical Report
Publication Date
Jan 29, 1985
Accession Number
ADA179431

Entities

People

  • James H. Shaw
  • Robert R Wolfe

Organizations

  • University of Texas Medical Branch

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Bacteria
  • Blood
  • Carbohydrates
  • Cardiovascular Physiological Phenomena
  • Chemistry
  • Chromatography
  • Fatty Acids
  • Gas Chromatography
  • Glucose Metabolism Disorders
  • Metabolic Diseases
  • Metabolism
  • Nervous System
  • Rodents
  • Sympathetic Nervous System
  • Veins
  • Vena Cava

Readers

  • Analytical Chemistry
  • Cardiovascular Physiology
  • Systems Analysis and Design