Phosphoprotein Regulation of Synaptic Reactivity: Enhancement and Control of a Molecular Gating Mechanism.

Abstract

This research is focussed on the role of molecular switches in brain which regulate synaptic reactivity. We have indentified a 47,000 mol wt phosponprotein and its kinase (C) which play a pivotal role in this regulation. We have enhanced communication among nerve cells studied electrophysiologically by activation of this kinase. In the proposed research we specifically manipulate this brain phosphoprotein with novel kinase activating agents. In a new initiative, both the kinase and the F1 substrate will be cloned with the goal of enchancing synaptic reactivity by regulating the expression of proteins that play a pivotal role in this process. Keywords: Synapse; Plasticity; Phosphorylation; Fatty acids; Lontophopersis.

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Document Details

Document Type
Technical Report
Publication Date
Feb 23, 1987
Accession Number
ADA179463

Entities

People

  • Aryeh Routtenberg

Organizations

  • Northwestern University

Tags

Communities of Interest

  • Space

DTIC Thesaurus Topics

  • Biological Sciences
  • Brain
  • Cells
  • Cellular Structures
  • Chemistry
  • Fatty Acids
  • Membrane Proteins
  • Nervous System
  • Neurons
  • Neurosciences
  • New York
  • Oleic Acid
  • Phosphorylation
  • Plastic Properties
  • Proteins
  • Regulations
  • Synapses

Fields of Study

  • Biology

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