Direct Assessment of Synaptic Modification Rules.
Abstract
This research has related experimental data on synaptic modification to the development of algebraic synaptic modification rules. The experimental findings support the following ideas: 1) There is a threshold for either synaptic potentiation or depression in dentate hyrus cells; 2) both potentiation and depression are equally long-term and are thus treated equally in the synaptic modification rule equation; 3) associativity means co-activity between pre- and postsynaptic elements; 4) the rate of change with successive conditioning trains is consistent with a steep sigmoid or binary process rather than a linear process. The results suggest that excitatory synaptic potentiation might occur via three mechanisms: more transmitter release, more conductance through the spine stems of potentiated synapses.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 20, 1987
- Accession Number
- ADA179548
Entities
People
- William B. Levy
Organizations
- University of Virginia