Effect of Atropine and 2-PAM Chloride on Vision and Performance.
Abstract
The effects on human volunteers of atropine in doses of 2 and 4 mg/70 kg body weight, 2-PAM CL Chlorine in doses of 600 and 1200 mg/70 kg and all possible combinations of these two anticholinergic drugs are described on a tank tracking simulator task (BLASER), and on a battery of visual functions, and on selected cardiovascular measures as well as on cognitive/memory function. The majority of effects of the combination doses can be predicted from the atropine results. 2-PAM CL has no effect on any measured function. The doses containing 4 mg atropine produced significant loss of tracking performance with peak loss occuring around 3 hours after injection. Signs of recovery were noted at 4 hours. The lower doses of atropine alone and in combination with 2-PAM CL had no effect on tracking. Atropine alone and in combination with 2-PAM CL produced long lasting visual side-effects. A small but significant potentiation of effects occurred for the high dose combination on several peripheral visual functions and some cardiovascular measures. Atropine (4 mg) was also found to affect retinal color mechanisms. No effect was found on memory/cognitive function. The time course of effects are delineated for each measure. Cardiovascular measures have a rapid time course, tracking performance loss shows an intermediate time course and the peripheral visual functions show a very prolonged time course.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 31, 1986
- Accession Number
- ADA179796
Entities
People
- Anthony J. Adams
- Arthur Jampolsky
- Gunilla Haegerstrom-portnoy
- Reese E. Jones