An Investigation of the Causes of the Blood Platelet 'Storage Lesion'.

Abstract

The role of thrombin in the platelet storage lesion has been examined and identified. We have shown that citrate formulations do not completely block the generation of thrombin during the preparation and storage of platelet concentrates. There is presented evidence that stored platelets and residual free calcium ions provide a support mechanism for formation of the prothrombinase complex in platelet concentrates. The addition of specific thrombin inhibitors and general inhibitors and general inhibitors of platelet activation to citrate anticoagulants for platelet concentrates has resulted in remarkably improved storage characteristics as assessed by in vitro markers. We believe that these studies provide a sound basis for the further investigation of the effectiveness of novel anticoagulants for use in the preparation and storage of platelet concentrates. Keywords: Human blood donors; Fibrinopeptide A; Antithrombin III.

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Document Details

Document Type
Technical Report
Publication Date
Apr 22, 1986
Accession Number
ADA180129

Entities

People

  • Arthur P. Bode
  • David T. Miller

Organizations

  • University of North Carolina at Chapel Hill

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Anticoagulants
  • Blood
  • Blood Coagulation
  • Blood Coagulation Factor Inhibitors
  • Blood Coagulation Factors
  • Cellular Structures
  • Chemistry
  • Contracts
  • Demographic Cohorts
  • Inhibitors
  • Measurement
  • Medical Personnel
  • North Carolina
  • Platelet Activation
  • Prothrombin
  • Tissue Donors

Readers

  • Immunology and Pathology
  • Materials Science.
  • Systems Analysis and Design