Evaluation of the Acute Toxicity of Selected Groundwater Contaminants

Abstract

Acute dermal and inhalation toxicology studies were conducted on several selected groundwater contaminants to provide additional data for hazard evaluations by Air Force personnel. Four of the compounds; Tetrachloroethylene, 1,1,1 -Trichloroethane, Chlorobenzene, and 1,1-Dichloroethylene were tested for acute dermal toxicity; 2,3-Dimethylphenol and 1,1-Dichloroethane were tested for acute 4-hour inhalation toxicity. Rabbits dermally treated with an upper limit dose of 2 ml/kg did not demonstrate symptoms of toxicity. Saturated vapors of 2, 3-Dimethylphenol did not result in mortality among exposed rats after 4 hours. However, 4-hour inhalation exposures to 1,1-Dichloroethane predicted an LC50 of approximately 13,000 ppm when using male rats. Keywords: Lethal concentration; Toxins.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1987
Accession Number
ADA180198

Entities

People

  • Edwin R. Kinkead
  • Harold F. Leahy

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Air Force Personnel
  • Biomedical Research
  • Body Weight
  • Chlorobenzene
  • Classification
  • Contractors
  • Contracts
  • Detectors
  • Ecology
  • Governments
  • Materials
  • Standards
  • Test And Evaluation
  • Toxic Hazards
  • Toxicity
  • Toxicology

Fields of Study

  • Environmental science

Readers

  • Groundwater Contamination Remediation.
  • Toxicology/Environmental Toxicology