Evidence for an Involvement of NMDA (N-methyl-D-aspartate) Receptor Mechanisms in Experience-Dependent Plasticity of Kitten Striate Cortex.
Abstract
Intracortical infusion of the NMDA ('N-methyl-D-aspartate') receptor blocker 2-amino-5-phosphonovaleric acid (APV) renders kitten striate cortex resistant to the effects of monocular deprivation. In addition, one week of APV treatment produces a striking loss of orientation selectivity in area 17. These data support the hypothesis that crucial variables for the expression of activity dependent synaptic modifications are a critical level of postsynaptic activation and calcium entry through gates linked to NMDA receptors.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 20, 1987
- Accession Number
- ADA180858
Entities
People
- A. Kleinschmidt
- M. F. Bear
- W. Singer
Organizations
- Brown University