Triazolam - Performance Side Effects: Vestibular, Musculoskeletal, and Complex Performance Tests.

Abstract

Transient insomnia preceding or during intense military aviation operations has, in some cases, been treated by short-acting benzodiazepines like temazepam or triazolam. This study evaluated selected physiological and performance side effects of triazolam (0.25 mg) administered to nine men and one woman. Each subject completed drug and placebo testing, which started at one and eight hours following drug administration. Testing included measures of balance, fine motor movement, two-dimensional tracking, tilt table, tri-service performance assessment battery, pulmonary function, bike ergometer, and strength/endurance. This dose of triazolam produced no significant change in any of the tests with the exception of the balance tests. This study did not identify any significant performance side effects that would disqualify this agent for acute short-term use against insomnia sometimes encountered in the military aviation environment. Keywords: Sleep deprivation; Aerospace medicine.

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Document Details

Document Type
Technical Report
Publication Date
Mar 04, 1987
Accession Number
ADA180934

Entities

People

  • C. A. Dejohn
  • D. M. Murdoch
  • G. G. Reams
  • J. M. Lentz

Organizations

  • Naval Aerospace Medical Research Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Availability
  • Cardiovascular Physiological Phenomena
  • Classification
  • Department Of Defense
  • Environment
  • Ergometers
  • Heart Rate
  • Insomnia
  • Instructions
  • Military Aviation
  • Performance Tests
  • Pulmonary Function
  • Security
  • Sequences
  • Side Effects
  • Two Dimensional
  • United States

Readers

  • Exercise and Sports Science.
  • Neurotoxicology
  • Space Exploration and Orbital Mechanics.

Technology Areas

  • Space