Effects of Atropine, 2-PAM, or Pyridostigmine in Euvolemic or Hemorrhagic Conscious Swine.
Abstract
We investigated the effects of atropine, pralidoxime chloride (2-PAM), or pyridostigmine on the physiological and metabolic responses to hemorrhagic hypotension in conscious swine. All treatments were evaluated in euvolemic and hemorrhaged animals (36 ml of blood/kg/over one hour). Hemorrhage reduced blood pressure by 58 mmHg and decreased plasma acetylcholinesterase (AChE) activity by 18% in the control animals (n=6). Atropine injection increased heart rate similarly in hemorrhaged (n=6) and euvolemic (n=6) animals. Blood pressure was also transiently elevated following atropine administration. Injection of 2-PAM acutely elevated the levels of plasma lactate and plasma AChE, but values were similar to those in the untreated animals within 15 min in both euvolemic (n=7) and hemorrhaged (n=7) animals. Treatment with pyridostigmine for 3 days reduced plasma AChE by 37% and red blood cell AChE by 35% (n=12). Pretreatment with pridostigmine had no effect on any of the responses to hemorrhage. Posthemorrhage treatment with atropine or 2-PAM or pretreatment with pyridostigmine had no detrimental effects on the physiological or metabolic responses to moderate hemorrhage in conscious swine. Keywords: Wounds and injuries; Trauma.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1987
- Accession Number
- ADA181041
Entities
People
- B. F. Williams
- Charles E.W. Wade
- D. S. Trail
- G. D. Bonner
- P. P. Waring
Organizations
- Letterman Army Hospital