Therapeutic Approaches to the Treatment of Botulism

Abstract

In vitro experiments have been done on isolated phrenic nerve- hemidiaphragm preparations. The purpose of the experiments was to evaluate aminopyridines as putative therapeutic agents in the treatment of botulism and to develop monoclonal antibodies that would neutralize botulinum toxin and tetanus toxin. The work demonstrates that aminopyridines are active against type A botulinum toxin. Research on antibodies is still in progress. Keywords: Antidotes; Botulism; Food poisoning.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1986
Accession Number
ADA181603

Entities

People

  • Lance L. Simpson

Organizations

  • Thomas Jefferson University

Tags

DTIC Thesaurus Topics

  • Amines
  • Amino Acids
  • Anesthesia
  • Botulism
  • Chemical Synthesis
  • Chemistry
  • Cholinergic Nerves
  • Diseases And Disorders
  • Food Poisoning
  • Muscles
  • Nerves
  • Nervous System
  • Peripheral Nervous System
  • Phrenic Nerves
  • Poisoning
  • Skeletal Muscle
  • Tissues

Readers

  • Microbial Pathology
  • Neurotoxicology