Synthesis of Nucleoside Mono- and Dialdehydes as Antiviral Agents.

Abstract

Seven nucleoside 2', 3' -dialdehydes were synthesized by periodic oxidation of inosine, 6-methylmercaptopurine riboside, thymine riboside, guanosine, 5'-fluoro-5'deoxyadenosine, 8-bromoadenosine, and N6, N6-dimethylaminopurine riboside, respectively. The resultant nucleoside dialdehydes, as well as the intermediate 5'-fluoro-5'deoxyadenosine, were submitted to the USAMRIID antiviral screening program. Keywords: Antiviral agents.

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Document Details

Document Type
Technical Report
Publication Date
Dec 15, 1986
Accession Number
ADA181691

Entities

People

  • John P. Neenan

Organizations

  • Rochester Institute of Technology

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antiviral Agents
  • Biomedical Research
  • Chemical Synthesis
  • Chemistry
  • Chromatography
  • Dna Viruses
  • Health Services
  • Hydroxides
  • Infectious Diseases
  • Iodine Compounds
  • Mass Spectra
  • Materials
  • Melting Point
  • Rna Viruses
  • Spectra
  • Thin Layer Chromatography
  • Viruses

Fields of Study

  • Chemistry

Readers

  • Electrochemical Engineering/ Fuel Cell Technologies
  • Parasitology and Pharmacology of Malaria.