A Program for Study of Skeletal Muscle Catabolism Following Physical Trauma.
Abstract
This contract examines methods of attenuating post traumatic metabolic responses. The increased glucose production which occurs following infection and injury in sleep was not decreased by infusion of beta-hydroxybutyrate; similar studies in normal of fasting animals demonstrated prompt attenuation. Net proteolysis following operation was reduced by amino acid infusion. Solutions fortified with branched chain amino acid exerted no beneficial effect. Post traumatic skeletal muscle proteolysis could be attenuated by alpha and beta adreneric blockade or epidural anesthesia. Skeletal muscle nitrogen balance could be predicted from branched chain amino acid uptake and changes of amino acid concentrations in the free amino acid pool. Keywords: Skeletal muscle proteolysis, Glutamine, Branched chain amino acids, Adrenergic regulation.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 15, 1986
- Accession Number
- ADA182019
Entities
People
- Douglas W. Wilmore
Organizations
- Harvard Medical School