The Synthesis and Study of Azole Carboxamide Nucleosides as Agents Active Against RNA Viruses.

Abstract

In an effort to prepare compounds with potential antiviral activity against RNA viruses having substantial implications from a global epidemiological standpoint, a number of azole heterocycles and the corresponding nucleosides structurally related to ribavirin have been synthesized. 1,2,4-Triazole, thiazole, pyrrole, pyrazole, purine, pyrrolo(2,3-d) pyrimidine and pyrimido(5,4-d) pyrimidine ring systems have particularly been selected. New and improved synthetic procedures have been developed during the course of this study. The compounds thus synthesized in gram quantities were tested at the U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, against RVF, VEE, PITCH, YF, SF, VSV, and KHF viruses in vitro and in vivo. Keywords: Ribaviran, Rift Valley fever virus; Lass virus; Machupovirus; Dengue virus; Pichinde virus; Hantaan virus; Retroviruses.

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Document Details

Document Type
Technical Report
Publication Date
Sep 15, 1986
Accession Number
ADA182716

Entities

People

  • Ganapathi R. Revankar
  • Roland K. Robins

Organizations

  • Brigham Young University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antiviral Agents
  • Chemical Synthesis
  • Chemistry
  • Chemotherapy
  • Crystal Structure
  • Data Analysis
  • Infection
  • Medical Personnel
  • Nucleosides
  • Organic Chemistry
  • Rift Valley Fever
  • Rna Viruses
  • Spectra
  • Virus Diseases
  • Viruses

Readers

  • Organic Chemistry
  • Parasitology and Pharmacology of Malaria.
  • Virology (or Medical Virology).