Final Technical Report on Contract N00014-83-D-0689,

Abstract

The catalytic hydrolysis of Diisopropylflurophosphate (DEP) and other phosphorus esters have been of great interest to the Navy. The discovery of the enzymes DFPase shows great promise for the hydrolysis of DEP, but a major problem with enzymes is their poor stability and limited available quantities. By investigating the use of enzyme mimics for the hydrolysis of Dep the stability and quantity problems can be avoided. One of the best known molecules used in biomimetic studies is cyclodextrin (CD). In this research we studied the inclusion complex of DFP with alpha, beta, and gamma cylcodextrin using Nuclear Magnetic Resonance(NMR) techniques. Cyclodextrins are cyclic oligomers of glucose.

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Document Details

Document Type
Technical Report
Publication Date
Jul 17, 1987
Accession Number
ADA182764

Entities

People

  • Kathleen S. Hall

Organizations

  • American Society for Engineering Education

Tags

Communities of Interest

  • C4I
  • Weapons Technologies

DTIC Thesaurus Topics

  • Alcohols
  • Aromatic Compounds
  • Aromatic Hydrocarbons
  • Chemical Shifts
  • Chemical Synthesis
  • Chemistry
  • Magnetic Resonance
  • Materials
  • Methanols
  • Mixtures
  • Molecules
  • Nuclear Magnetic Resonance
  • Organic Chemistry
  • Phosphorus
  • Resonance
  • Solvents

Readers

  • Molecular and Cellular Biochemistry
  • Neurotoxicology
  • Systems Analysis and Design

Technology Areas

  • Biotechnology