The Primary Structure of Acetylcholinesterase and Selective Antibodies for the Detection of Organophosphate Toxicity.
Abstract
The proposed work has been directed to determination of the structure of acetylcholinesterase. During the project period we have determined the primary structure of the Torpedo enzyme through amino acid sequencing and the isolation and sequencing of a c-DNA clone encoding for the 11S form of the enzyme. Peptides corresponding to the active center of the enzyme and a C-terminal region have been synthesized and antibodies are being raised for the purpose of detecting the phosphorylated enzyme and delineating functional regions of the molecule. Finally, progress has been made on the secondary structure of the enzyme. Keywords: Biochemistry.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 03, 1985
- Accession Number
- ADA182953
Entities
People
- Palmer W. Taylor
Organizations
- University of California, San Diego