Development of Synthetic Catalysts for Peptide Bond Cleavage (Synthesis and Complete Kinetic Analysis of Compounds 6A, 7A, 8A).
Abstract
Synthetic mimics for carboxypeptidase A will be synthesized and the structural and chemical factors responsible for catalytic peptidase activity will be probed. Ditopic macrocyclic receptors have been designed which incorporate the salient features of the enzyme analog, namely high affinity complex formation, general base and general acid catalysis, and covalent catalysis. Once synthesized the resulting macrocycle-metal ion complexes should non-specifically promote the hydrolysis of C-terminal peptide bonds. The initial macrocycles, ammonium and ether oxygens. One side of ditopic receptor will preferentially bind zinc (II) ion, the other the peptide substrate.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 05, 1987
- Accession Number
- ADA183251
Entities
People
- Kristin B. Mertes
- Mathias P. Mertes
Organizations
- University of Kansas