Structure and Design of Multipotent Peptide Microbicides.
Abstract
A family of antimicrobial leukocyte peptides has been iolated from the neutrophils of several species. I am using the concensus structure of the peptides (known as defensins) as a molecular foundation for generating new antimicrobial peptides by synthetic methods. The synthetic approach is directed by correlating the solution structures of various defensins with their distinctive bilogical activities. Report consists of a brief description of recent accomplishments.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1987
- Accession Number
- ADA183649
Entities
People
- Michael E. Selsted
Organizations
- University of California, Los Angeles