The Metabolism of Nitroguanidine and Nitrosoguanidine by Rat Hepatic Subcellular Fractions,

Abstract

The metabolism of nitroguanidine (NG) and nitrosoguanidine (NsG) by rat hepatic subcellular fractions was examined. The microsomal fraction and 10,000 x g supernatant from untreated and phenobarbital - treated animals and the 9,000 x g supernatant from Arochlor-induced rats were used for this study. The in vitro metabolism of substrate was measured by HPLC. The results indicate that neither NG nor NsG are metabolized by the hepatic subcellular fractions.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1987
Accession Number
ADA183744

Entities

People

  • Bert Ho
  • Don W. Korte Jr.
  • Paul B. Simboli

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Animals
  • Cells
  • Databases
  • Department Of Defense
  • Incubation
  • Laboratory Animals
  • Materials
  • Metabolism
  • Microsomes
  • Nitroguanidine
  • Nitroso Compounds
  • Propellants
  • Subcellular Fractions
  • Technical Information Centers
  • Triple Base Propellants
  • United States
  • United States Government

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biochemistry
  • Toxicology/Environmental Toxicology