Primary Eye Irritation of Guanidine Hydrochloride in Rabbits

Abstract

The primary eye irritation potential of guanidine hydrochloride was determined in male New Zealand White rabbits using a modified Draize method. The compound produced irritation in all animals tested. Signs of irritation were erythemaz and chemosis of the conjunctiva, iritis, and corneal lesions. These results indicate that guanidine hydrochloride should be classified as an ocular irritant. Keywords: Primary Eye Irritation, Guanidine Hydrochloride, Mammalian Toxicology ogy, Nitroguanidine, Munition, Explosives, Rabbit.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1987
Accession Number
ADA184068

Entities

People

  • Don W. Korte Jr.
  • Larry D. Brown
  • Thomas P. Kellner

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Animal Structures
  • Biological Sciences
  • Biomedical Research
  • Chemical Analysis
  • Classification
  • Dyes
  • Eye
  • Eye Diseases
  • Laser Dyes
  • Materials
  • Membranes
  • Military Research
  • New Zealand
  • Nitroguanidine
  • Quarantine
  • Toxicology
  • Triple Base Propellants

Readers

  • Toxicology/Environmental Toxicology