The Effect of an Experimental Missile Wound to the Brain on Brain Electrolytes, Regional Cerebral Blood Flow and Blood Brain Barrier Permeability.
Abstract
Brain wounds account for most deaths on the battlefield yet scarcely any research has been done on brain wounds caused by missiles. The purpose of this research was to develop a valid laboratory model of a brain wound and to study several clinically important physiologic variables altered by wounding. Better adjunctive medical treatments for brain wounds will be developed once the pathophysiology of brain wounding is understood. We have a laboratory model for painlessly creating a uniform brain wound in anesthetized cats and have studied several physiologic variables altered by brain wounding. We make the brain wound by a helium powered gun which fires a 2mm diameter, 31mg, steel sphere across a velocity gate and through a cat's intact skull. Prior to wounding, the cat is precisely positioned in front of the gun in a stereotaxic frame. Missile energy is calculated from measured velocity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 10, 1987
- Accession Number
- ADA184072
Entities
People
- Gurcharan G. Sarna
- J. B. Farrell
- Michael E. Carey
Organizations
- LSU Health Sciences Center New Orleans