Synthetic Helizyme Enzymes.
Abstract
The object of this project is to design and synthesize totally new, totally synthetic small molecules having specific enzyme activity. The ultimate goal is to design and synthesize a molecule with cholinesterase activity. The initial goal is to design and synthesize a molecule with chymotryspin activity. Computer-assisted molecular graphics is being used to model chymotryspin from the known X-ray structure and extract the amino acid residues responsible for catalytic activity and substrate binding. A synthetic framework of amphipathic helical peptides is being designed and will be synthesized to hold the essential amino acid residues in the conformation necessary for enzyme activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 18, 1987
- Accession Number
- ADA184413
Entities
People
- John M. Stewart
- Karl Hahn
Organizations
- University of Colorado Health