Subchronic Toxicity Study on 1,4-Dithiane.

Abstract

This 90-day investigation was undertaken to determine the subchronic toxicologic and pathologic effect(s), if any, of 1,4-dithiane in the rat. Several doses (three doses per sec as well as a control) were used in order to obtain as much information as possible at non-toxic dose levels. In a preliminary 14-day range-finding study, rats were gavaged daily at 0,25, 50, 100, 210 and 420 mg/kg/day (6 rats/sex/dose). No overt toxicity or mortality was observed. The female livers and the make kidneys were significantly heavier in the treated animals. There was deposition of anisotropic crystals of an undetermined chemical composition in the nasal olfactory mucosa of both sexes of the high and intermediate dose groups. The livers of the high dose females contained two hepatocellular lesions: minimal hypertrophy in the centrilobular region and minimal cytoplasmic vacuolation in the periportal region.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1987
Accession Number
ADA184771

Entities

People

  • George J. Schieferstein

Organizations

  • National Center for Toxicological Research

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Body Weight
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Chlorides
  • Data Analysis
  • Data Science
  • Health Services
  • Information Science
  • Laboratory Animals
  • Medical Personnel
  • Mucous Membrane
  • Nose
  • Range Finding
  • Statistical Analysis

Readers

  • Toxicology/Environmental Toxicology