Human Thermoregulation After Atropine and/or Pralidoxime Administration
Abstract
The effects of intramuscular saline (control), atropine (2 mg), and/or pralidoxime (600 mg) on heat exchange was evaluated in four healthy males during seated, cycle exercise in a temperate environment. Esophageal, rectal, and mean skin temperatures, and chest and forearm sweating were continuously measured. Skin blood flow from (FBF) from the forearm was measured. Whole body sweating was calculated from weight changes. The expected result of atropine injection, decreased eccrine sweating and elevated esophageal and skin temperatures was observed relative to control. Heart rate and FBF (+9 ml 100ml-1 min-1) were higher after atropine. Pralidoxime, in general, did not affect the core and skin temperature responses to the exercise differently from control; however a slightly elevated FBF compensated for the reduction in whole body sweating that we observed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1987
- Accession Number
- ADA185352
Entities
People
- Bruce S. Cadarette
- Lou A. Stephenson
- Margaret A. Kolka
- Richard R. Gonzalez
- Stephen P. Bruttig
Organizations
- United States Army Research Institute of Environmental Medicine