A Program for the Study of Skeletal Muscle Catabolism Following Physical Trauma.

Abstract

Following laparotomy and retroperitoneal dissection, dogs increase skeletal muscle proteolysis and excrete increased quantities of nitrogen in the urine. Pretreatment with a cyclo-oxygenase inhibitor (Ibuprofen) diminished this response in the 5 animals studied to date. More animals are required to make firm conclusions as to the effectiveness of this therapy on post traumatic metabolism.

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Document Details

Document Type
Technical Report
Publication Date
Mar 15, 1987
Accession Number
ADA185436

Entities

People

  • Douglas W. Wilmore

Organizations

  • Brigham and Women's Hospital

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Anesthesia
  • Blood
  • Body Weight
  • Catabolism
  • Chemistry
  • Creatinine
  • Excretion
  • Health Services
  • Inhibitors
  • Laboratory Animals
  • Materials
  • Medical Personnel
  • Muscle Proteins
  • Nitrogen
  • Standards
  • Veins

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Toxicology/Environmental Toxicology
  • Trauma Surgery or Emergency Medicine.