Intrinsic Cholinergic Mechanisms Regulating Cerebral Blood Flow as a Target for Organophosphate Action.
Abstract
The hypothesis of this study is that intrinsic systems in the brain can produce primary vasodilation independent of metabolism, that the system is represented in the fastigial nucleus FN of the cerebellum, and that the vasodilation is mediated by the release of acetylcholine ACh adjacent blood vessels. The cholinergic vasodilation, which is maximum in the cerebral cortex, should be facilitated by organophosphates, the consequence of which will be to abolish local autoregulation, produce an enhanced dependence of the cerebral circulation upon systemic arterial pressure, and thereby render local cerebral vessels vulnerable to breakdown of the blood-brain barrier. Keywords: Cerebral blood flow; Muscarinic receptor blockade; Cholinergic vasodilation; Atropine.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1985
- Accession Number
- ADA185472
Entities
People
- Costantino Iadecola
- Donald J. Reis
- Stephen P. Arneric
Organizations
- Weill Cornell Medicine