Entropic Elastomeric Force in Protein Structure/Function.
Abstract
Entropic protein elasticity can be the result of internal chain dynamics, specifically of librational processes that become damped on chain extension. This mechanism of entropic protein elasticity allows for an understanding not only of elastin but also of the passive tension of striated muscle, of the voltage-dependent interconversion between open and closed conductance states in the sodium channel of squid nerve, and of protein elastic forces producing strain in a substrate bond during enzyme catalysis. This understanding provides a mechanism for modulating protein function, whether for example enzymatic or channel, a mechanism for the remarkable reversible structural processes that attend parturition, and mechanism for the connective tissue anomalies of wound repair and environmentally induced lung disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1987
- Accession Number
- ADA185490
Entities
People
- Dan W. Urry
Organizations
- University of Alabama at Birmingham