The Fibronectin Binding Capacity of Demineralized Bone and Dentin.
Abstract
An understanding of the basic biochemical and physiological mechanisms of wound healing is important when developing rationales for new therapies in periodontics and other surgical specialities. Reattachment or new attachment of connective tissue to root surface is frequently a goal of periodontal therapy. Experiments have recently been done to investigate the role of fibronectin in the healing of wounds involving periodontal tissues. Fibronectin is an ubiquitous glycoprotein found in both plasma and in various tissues. This study examines the fibronectin binding capacity of demineralized bone and dentin. The results indicate that in clinical use, bleeding into a surgical wound would provide endogenous fibronectin in concentrations sufficient to saturate all available collagen binding sites. The addition of exogenous fibronectin as a means of enhancing wound healing would appear to be unnecessary. Keywords: Thesis, Healing, Wounds and injuries, Dental surgery.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1986
- Accession Number
- ADA185558
Entities
People
- Bryan S. Pearson
Organizations
- Air Force Institute of Technology