Urinary and Hematologic Indexes of Hypohydration
Abstract
As part of a large-scale field feeding system test we were able to collect and study hundreds of aliquots of overnight urine samples obtained immediately prior to a fasting blood sample on days 1, 20, and 44 of the field test. The large number of experimental samples (more than 650) and concomitant collection of blood and urine aliquots along with data on body weights gave us the opportunity to assess and quantitate the sensitivity of commonly used criteria of hypohydration. Urine aliquots for all test days were initially categorized by specific gravity (SG). Creatinine levels were elevated (P less than 0.001) in the concentrated urine samples, but a decreased trend in sodium- to-potassium ratios in these samples failed to achieve statistical significance (P more than 0.05). Hematocrit and serum osmolality were not significantly different when examined by the criteria of high or low SG urine and weight loss or less than 3% original body weight. The results of this study indicated that mild hypohydration, manifested in concomitant elevations in urinary SG and creatinine, was not reflected in the common circulatory indexes of hypohydration, i.e., hematocrit and osmolality. Alternatively, urea nitrogen-to- creatinine ratio may be a sensitive circulatory index of imminent hypohydration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1987
- Accession Number
- ADA185593
Entities
People
- D. Carlson
- D. Schnakenberg
- P. C. Szlyk
- R. P. Francesconi
- R. W. Hubbard
Organizations
- United States Army Research Institute of Environmental Medicine