Red Cell Storage Studies.
Abstract
Efforts were focused in 5 major areas: we established a strong correlation between in vitro red cell deformability measurements an in vivo red cell survival measurements. We found that a red cell deformability defect could be induced by an increase in membrane instability secondary to a calcium: calmodulin interaction which may occur in stored cells. In collaborative studies, we found that appreciable membrane vesiculation occurs during in vitro storage under blood bank conditions. We studied the antibody-mediated accumulation of gamma-globulin on red cells and some of the mechanism of this process both with regards to the so-called 'senescent' antigen, and the anti-Gal antigen. We re-examined the assumption that cell age is directly related to cell density, and concluded that a simple correlation of cell age is not tenable. Keywords: Blood storage; Membranes(Biology); Blood cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 15, 1987
- Accession Number
- ADA185617
Entities
People
- Stephen B. Shohet
Organizations
- University of California, San Francisco