Studies of Infection and Dissemination of Rift Valley Fever Virus in Mosquitoes.

Abstract

WE ARE ENGAGED IN A MULTIMETHOD STUDY OF Rift Valley fever virus in vector and hypothetical vector mosquitoes. We have found that (1) early dissemination and possible early or rapid transmission can occur in Culex pipiens; (2) evidence from several standpoints supports the idea of virus escape from the gut lumen in the region of the foregut-midgut junction; (3) the basal lamina may act as a midget barrier of at least retard viral passage; (4) RVF virus is capable of infecting most tissues in the mosquito hemocoel and may exert its pathological effects both by general depletion of energy stores and by interfaces with regulatory proceses; (5) the fat body may be an important amplifying tissue; (6) in Aedes mcintoshi, a species strongly suspected of transovarially maintaining RFV in Kenya, the follicular epithelia and eggs are, at least in some cases, susceptible to infection. Keywords: Disease vectors.

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Document Details

Document Type
Technical Report
Publication Date
Jul 02, 1987
Accession Number
ADA185680

Entities

People

  • William S. Romoser

Organizations

  • Ohio University

Tags

DTIC Thesaurus Topics

  • Animal Structures
  • Antigens
  • Arbovirus Infections
  • Bodies
  • Cells
  • Electron Microscopy
  • Endoplasmic Reticulum
  • Epithelial Cells
  • Epithelium
  • Health Services
  • Infectious Diseases
  • Morphogenesis
  • Rift Valley Fever
  • Rift Valleys
  • Salivary Glands
  • Tissues
  • Viruses

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Vector-Borne Disease and Entomology
  • Virology (or Medical Virology).