Biopolymers: Protein and Nucleic Acids
Abstract
The work focuses on learning the principles that govern interactions between proteins and nucleic acids. With these principles as guides we are synthesizing peptides (of about 50 amino acids) that bind to specific regions of DNA. Various reactive functionalities are being attached to the synthetic peptides to generate reagents that cleave DNA specifically at the site to which the peptide binds. The work also involves biophysical and theoretical studies of the protein/nucleic acid complexes in order to expand our understanding of the principles of protein binding to nucleic acid as well as the development of improved procedures for the chemical synthesis of peptides. Keywords: DNA binding; Synthetic peptides; Reagents for DNA cleavage; Nucleic acids; Protein structure; Deoxyribonucleic acids.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 15, 1987
- Accession Number
- ADA185837
Entities
People
- John H. Richards
- John N. Abelson
- Judith L. Campbell
- Leroy E. Hood
- Melvin I. Simon
Organizations
- California Institute of Technology