Increased Dissemination of Dengue 2 Virus in Aedes aegypti Associated with Concurrent Ingestion of Microfilariae of Brugia malayi
Abstract
We investigated whether concurrent ingestion of dengue 2 virus and microfilariae of Brugia malayi would increase viral infection and dissemination rates in Aedes aegypti. Infection rates were similar in mosquitoes that ingested virus along or both virus and microfilariae concurrently. However, viral dissemination rates, as determined by recovery of dengue virus from both legs and bodies separately, were significantly greater in mosquitoes that ingested both agents concurrently than in those that ingested virus alone. This study confirms that vectorial capacity of a natural vector of an arbovirus may be enhanced by the concurrent ingestion of microfilariae.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1987
- Accession Number
- ADA185955
Entities
People
- Andrew Spielman
- Charles L. Bailey
- Michael J. Turell
- Thomas N. Mather
Organizations
- United States Army Medical Research Institute of Infectious Diseases