Pharmacological Resetting of the Circadian Sleep-Wake Cycle.

Abstract

This research project is investigating strategies to pharmacologically manipulate the circadian sleep-wake cycle in order to control the timing of alert function and of sleep in altered work schedule environments. In the past year we have investigated the benzodiazepines,diazepam (in hamsters) and triazolam (in squirrel monkeys), and have derived a phase response curve for each. In optically-enucleated hamsters, however, consistent phase shifts were not obtained suggesting that diazepam acts on light information-conveying pathways. Biochemical receptor binding studies are defining the benzodiazepine receptor density in various brain regions. In addition, the characterization of the circadian and homeostatic components of sleep in the squirrel monkey during sleep deprivation studies is being conducted in preparation for pharmacological manipulation with benzodiazepines. Keywords: Mathematical modeling; Jet-lag.

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Document Details

Document Type
Technical Report
Publication Date
May 30, 1987
Accession Number
ADA186194

Entities

People

  • Martin C. Moore-ede

Organizations

  • Harvard Medical School

Tags

Communities of Interest

  • Advanced Electronics
  • Energy and Power Technologies
  • Space

DTIC Thesaurus Topics

  • Air Force
  • Animals
  • Anticonvulsants
  • Biological Sciences
  • Brain
  • Circadian Rhythms
  • Deprivation
  • Diseases And Disorders
  • Jet Lag
  • Medical Personnel
  • Monkeys
  • Phase Shift
  • Rodents
  • Scientific Research
  • Sleep Deprivation
  • Sleep Disorders
  • Squirrel Monkeys

Fields of Study

  • Biology
  • Psychology

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Molecular and Cellular Biochemistry
  • Toxicology/Environmental Toxicology