Pyridostigmine, 2-PAM and Atropine: Effects on the Ability to Work in the Heat,
Abstract
Adult, male rats had access to either tap water or tap water containing 300 mg/L of pyridostigmine bromide (PYR) for 1 week prior to experimentation; this was followed by exercise at 30 C to hyperthermic exhaustion. Thirty min prior to the exercise, pyridostigmine (PYR) - and water-drinking groups were treated with an additional intraperitoneally administered regimen: saline, atropine sulfate, pyridine-2-aldoxime methiodide, or atropine plus pyridine-2-aldoxime methiodide. PYR rats drank significantly more than their tap water drinking counterparts although mean daily food consumption was unaffected by PYR. Mean endurances ranged from 50.4 min (PYR-ATR-2-PAM) to 76.3 min (PYR). The 4 groups receiving 2-PAM manifested a mean endurance of 53.9 min while the 4 groups not receiving 2-PAM had a mean endurance of 66.2 min. PYR-pretreatment elicited a 25% inhibition of plasma cholinesterase while in the two groups consuming PYR and treated with 2-PAM, inhibition was approximately 10%. Osmolality, lactic acid dehydrogenase, creatinine, urea nitrogen, and lactate were elevated by the heat-exercise. There were indications (endurance capacity and CPK efflux) that 2-PAM may have subsequent adverse effects on the ability to work in the heat. While indices of heat/exercise injury were ordinarily increased by exercise in the heat, elevations were generally unaffected by pharmacological intervention.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1987
- Accession Number
- ADA186459
Entities
People
- C. B. Matthew
- M. Bosselaers
- N. Leva
- R. P. Francesconi
- R. W. Hubbard
Organizations
- United States Army Research Institute of Environmental Medicine