Annual Report: September 1987.

Abstract

The molecular mechanism underlying the voltage dependence of the mitochondrial channel, VDAC, is the general aim of the research. The approaches used to move toward that goal were: succinic anhydride modification, regulation by aqueous aluminum species and polyanions, and kinetic analysis. The results indicate that the voltage sensor and selectivity filter are distinct groups of charges, probably amino groups. The sensor is probably not located in the channel proper but on one or the other surfaces of the membrane where it can interact with high molecular weight polyanions. The kinetic studies are in their early stages but indicate the presence of unusual physical phenomena. Keywords: Membranes(Biology); Membrane channel; Voltage dependence; Aluminum; Polyanion protein modification.

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Document Details

Document Type
Technical Report
Publication Date
Sep 28, 1987
Accession Number
ADA186580

Entities

People

  • Marco Colombini

Organizations

  • University of Maryland

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Acquisition
  • Aluminum
  • Anhydrides
  • Availability
  • Classification
  • Kinetics
  • Magnetic Fields
  • Membranes
  • Military Research
  • Molecular Weight
  • Regulations
  • Security
  • Universities

Readers

  • Molecular and Cellular Biochemistry
  • Plasma Physics.