Effects of Organophosphate Esters on Neuropeptide Systems.

Abstract

Organophosphate esters were studied in terms of their ability to affect neuropeptides in the rat central nervous system. The in vivo biosynthesis of enkephalin peptides in the basal ganglia and of vasopressin and oxytocin in the hypothalamus were studied and the effect of subcutaneous administration of diisopropylfluorophosphate (DFP) in the biosynthesis of these neuropeptides was assessed. It was found that DFP inhibited the biosynthesis of vasopressin and oxytocin. These results suggest that organophosphates exert their effects not only on cholinergic systems but also on neuropeptide systems important in endocrine and cardiovascular function.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1986
Accession Number
ADA186594

Entities

People

  • Jeffrey F. Mckelvy

Organizations

  • State University of New York at Albany

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Brain
  • Central Nervous System
  • Endocrine Glands
  • Hypothalamus
  • Laboratory Animals
  • Liquid Chromatography
  • Nervous System
  • Neurons
  • Neurosciences
  • Neurotransmitter Agents
  • New York
  • Peptides
  • Physiological Processes
  • Pituitary And Hypothalamic Hormones And Analogues
  • Pituitary Glands
  • Spinal Cord

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Neuroscience
  • Neurotoxicology