Molecular Dynamics of Calmodulin.

Abstract

Our longterm objective is an understanding of the molecular basis of calmodulin activation of target enzymes. We have chosen the interaction of calmodulin with peptides as an initial paradigm to simplify the study of the molecular details of the peptide-protein interaction. Our initial focus has been the development of methodology for the experimental study of the molecular dynamics of calmodulin binding-peptides, and of calmodulin-peptides complexes, in particular an evaluation of the conjoint use of fluorescence and NMR spectroscopy in such studies.

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Document Details

Document Type
Technical Report
Publication Date
Aug 15, 1987
Accession Number
ADA186687

Entities

People

  • Franklyn G. Prendergast

Organizations

  • Mayo Clinic

Tags

Communities of Interest

  • Air Platforms
  • Energy and Power Technologies
  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Amino Acids
  • Classification
  • Dynamics
  • Fluorescence
  • Mathematical Analysis
  • Measurement
  • Molecular Dynamics
  • Molecular Mechanics Methods
  • Molecules
  • Picosecond Time
  • Resonance
  • Security
  • Simulations
  • Spectroscopy
  • Test And Evaluation
  • Tryptophan
  • X Rays

Fields of Study

  • Chemistry

Readers

  • Computational Modeling and Simulation
  • Molecular and Cellular Biochemistry