Long Term Synaptic Plasticity and Learning in Neuronal Networks.
Abstract
The working hypothesis has been that longterm synaptic potentiation may mediate certain of the mnemonic functions of the hippocampal circuitry. The discovery of an underlying Hebbian conjunctive mechanism has boosted confidence in this hypothesis. One major effort of the past year was to summarize and integrate this AFOSR supported discovery into a more general theoretical and experimental framework. In regard to the 4 specific aims, development of the fluctuation algorithm has been completed, and it was applied to synaptic fluctuations obtained using the loose patch clamp method (aim 2). THe algorithm is currently running on a mainframe at UCLA. It is now being implemented on a small workstation (Macintosh II). As soon as it is working on the Mac II, the quantal analysis in hippocampus will begin (aim 1). The culture method is underway (aim 3) and a first-generation video microscopic technique was developed for visualizing neurons and their synapses to see if the latter move during activity (aim 4).
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 14, 1987
- Accession Number
- ADA186834
Entities
People
- Thomas H. Brown