Effects of Trichothecenes on Cardiac Cell Electrical Function
Abstract
This year was devoted to elucidating the effects, if any, of intravenous T-2, roridin A, and other trichothecenes on the mammalian cardiovascular system. Effects were studied Effects were studied at whole animal and single cell levels. Reflex, cardiac, and hemodynamic effects were assessed in a whole animals while specific electrophysiologic effects on single cell action potentials were observed in isolated, perfused cardiac tissue where microelectrodes could be used and where neurohumoral factors could be controlled. These effects are described in detail in the Experimental Results section. Briefly, certain trichothecenes were observed to have direct effects on the heart and also on the peripheral circulation. However, there were frequently simultaneous effects on autonomic neural control (i.e. reflexes) of the cardiovascular system and further work must be done to unravel these complex interactions. Keywords: Response(Biology); Physiological effects.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 30, 1984
- Accession Number
- ADA186977
Entities
People
- W. T. Woods Jr.
Organizations
- University of Alabama