Phosphoprotein Regulation of Synaptic Reactivity: Enhancement of a Molecular Gating Mechanism.

Abstract

This research is focussed on the role of molecular switches in brain which regulate synaptic reactivity. We have identified a 47,000 mol wt phosphoprotein and its kinase (c) which play a pivotal role in this regulation. We have enhanced communication among nerve cells studied electrophysiologically by activation of this kinase. In the proposed research we specifically manipulate this brain phosphoprotein with novel kinase activating agents. In a new initiative, both the kinase and the F1 substrate will be studied with the goal of enhancing synaptic reactivity by regulating the activity of proteins that play a pivotal role in this process. Keywords: Nerve transmission; Synapse; Plasticity; Reactivity; Phosphorylation; Protein kinase C; Protein F1; Fatty acids.

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Document Details

Document Type
Technical Report
Publication Date
Aug 15, 1987
Accession Number
ADA187145

Entities

People

  • Aryeh Routtenberg

Organizations

  • Northwestern University

Tags

Communities of Interest

  • Materials and Manufacturing Processes
  • Space

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Brain
  • Cells
  • Diseases And Disorders
  • Fatty Acids
  • Medical Personnel
  • Nerves
  • Nervous System
  • Neurons
  • Phosphorylation
  • Plastic Properties
  • Proteins
  • Reactivities
  • Regulations
  • Substrates
  • Synapses

Fields of Study

  • Biology

Readers

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  • Neuroscience