Chronic Mammalian Toxicological Effects of LAP Wastewater.
Abstract
The objective of these studies was to provide a comprehensive definition of the long-term toxicological effects of LAP wastewater (TNT/RDX in a ratio of 1.6 to 1) on Fischer-344 rats with respect to possible lesions at the biochemical and cellular levels. Males receiving 200 mg/kg/day of LAP exhibited convulsions and death, the high-dose level was reduced to 100 mg/kg/day for both sexes after 12 weeks on test. Males at the mid-dose level showed an increase in mortality compared with controls at 104 weeks (study termination); these rats also exhibited convulsions and aggressive behavior. Low-dose males and females at both the low- and mid-dose levels showed little response with regard to behavioral or clinical abnormalities, food consumption, and mortality; however, body weights in these groups were significantly decreased throughout the study. Effects on both the myelocytic and erythrocytic series were seen in both sexes at the mid-dose level. A dose response was seen in glucose, uric acid, potassium, triglycerides, LDH, total iron, A/G ratio, sodium, CO2, and biluribin. Only LDH was significantly decreased in males at both levels. The principle LAP-induced lesions observed as histopathological examination were degenerative changes in the eye and urinary system and decreased cellularity of the lymphoid tissues.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1983
- Accession Number
- ADA187273
Entities
People
- Janice M. Brown
- Ronald J. Spanggord
- Ted A. Jorgenson
Organizations
- SRI International