Role of Adenosine Analogs and Growth Hormone in Waking and Sleep.

Abstract

The role of adenosine in sleep has been further investigated using electroencephalography to document the dose response effects of newly developed specific adenosine A1 and A2 receptor stimulants and 8-cyclopropyltheophylline (CPRT), a substituted xanthine. The results with adenosine agonist suggest that both A1 and A2 receptors play a role in the hypnotic action of adenosine. The data with CPRT point out that stimulant effects of xanthines is obtained by the blockade of A1 receptors. Densensitization of adenosine A2 receptors was found following the chronic treatment of adenosine agonists L-PIA, NECA ad deoxycoformycim. Chronic administration of caffeine up-regulates A1 receptors in cerebral cortex in a manner similar to that following deprivation of REM sleep. This suggests the existence of an endocaffeine whose normal role is to block adenosine receptors during prolonged sleep deprivation- a mechanism that could be responsible for the increased number of adenosine receptors. Keywords: Hypnosis; Physiological effects; Sleep deprivation.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 16, 1987
Accession Number
ADA187897

Entities

People

  • Miodrag Radulovacki

Organizations

  • University of Illinois Urbana–Champaign

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Adenosine
  • Air Force
  • Alkaloids
  • Analogs
  • Brain
  • Caffeine
  • Cerebral Cortex
  • Deprivation
  • Human Factors Engineering
  • Medical Personnel
  • Physiological Effects
  • Scientific Research
  • Sleep Deprivation
  • Wakefulness

Fields of Study

  • Medicine

Readers

  • Neurological Diseases/Conditions/Disorders
  • Neuroscience
  • Prostate Cancer Biology.