Testing of Compounds for Efficacy against Schistosomiasis.
Abstract
A total of 19 candidate compounds were tested for prophylactic activity in mice and hamsters. Two of these compounds (Zm65703 and BC78878) were studied and are not recommended for further evaluation as prophylactic candidate drugs. Of the remaining 17 compounds One (BL23702) was found to be highly active, with a protection level of 99.5% Only 2 worms (1 male and 1 female found in separate mice) were found during perfusion of the group of 10 treated mice which received a single dose of 100 mg/kg of drug for 5 consecutive days. No gross toxicity was observed for this compound. This drug is now being studied at an advanced test level in primates. Three other compounds (BL23695, BL23677 and BL23510) gave protection levels against S. mansoni (Kenyan strain) ranging from 91.0% to 94.9% respectively. For each of the mice treated with these compounds, mature adult male and female worms capable of depositing eggs in tissue, and thus causing pathology, were found. At the present time, no further studies on these compounds are contemplated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 25, 1987
- Accession Number
- ADA187950
Entities
People
- John I. Bruce