Influence of T-2 Mycotoxin on Host Resistance to Candida albicans Infections in Mice

Abstract

Mice infected with Candida albicans and then exposed to two or three doses of T-2 mycotoxin by the gastric route died earlier and in greater numbers than controls. The ability of livers, lungs, and spleens to clear and kill the organisms was compromised by exposing mice to multiple doses of toxin. A single dose of toxin given before or after Candida challenge did not increase the mortality. These studies add further information regarding biological effects of this mycotoxin, and shows that increased hazards are involved when this compound amplifies the pathogenesis of microorganisms such as C. albicans. Keywords: Phytotoxins, Toxicity.

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Document Details

Document Type
Technical Report
Publication Date
Apr 20, 1987
Accession Number
ADA188484

Entities

People

  • George C. Cozad
  • John F. Hewetson

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Bacteria
  • Biological Warfare
  • Biomedical Research
  • Cells
  • Fungi
  • Health Services
  • Inoculation
  • Lethality
  • Macrophages
  • Mycology
  • Propenes
  • Propylene Glycol
  • Research Facilities
  • Resistance
  • Southeast Asia
  • Toxicity

Fields of Study

  • Biology

Readers

  • Mycotoxin ecology in Amazonian ecosystems.
  • Oncology
  • Toxicology/Environmental Toxicology