Effects of Chronic Pyridostigmine Administration on Muscle Fatigue and Morphology.
Abstract
Pyridostigmine, a reversible anticholinesterase is used prophylactically against subsequent exposure to organophosphates. Yet, there is evidence from animal studies that reversible anticholinesterase agents can induce structural and functional abnormalities in the neuromuscular system. The damage appears to require a threshold exposure in time and dose, and can be prevented by prior denervation of the muscle, implying that the origin of the damage stems from the extended presence of acetylcholine (ACh) released into the neuromuscular junction from the presynaptic nerve, resulting in excessive activation of proteases by the influx of calcium at the motor endplate.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1987
- Accession Number
- ADA188697
Entities
People
- Martin Chipman
- Oded Abramsky
- Rachelle H. Fishman
- Zohar Argov