Mutagenic Potential of Nitrosoguanidine in the Mouse Lymphoma Forward Mutation Assay.
Abstract
The mutagenic potential of nitrosoguanidine (TP048) was assessed in the mouse lymphoma thymidine kinase forward mutation assay both with and without metabolic activation by rat liver S-9. In the initial and confirmatory assays, cells were exposed to test compound concentrations ranging from 1.5 mg/ml to 0.7 mg/ml. Nitrosoguanidine induced a significant increase in the mutant frequency in both assays. These results indicate that nitrosoguanidine was mutagenic under the conditions of this study. Keywords: Mutagenicity, Genetic toxicology, Mouse lymphoma assay, Nitrosoguanidine, Cytotoxicity, Propellants, Environmental hazards, Health hazards.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1987
- Accession Number
- ADA189001
Entities
People
- Don W. Korte Jr.
- John W. Harbell
Organizations
- Letterman Army Hospital